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KMID : 0644120220350030024
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Journal of Oriental Gynecology
2022 Volume.35 No. 3 p.24 ~ p.36
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Inhibitory effect of Citrus sunki and Cimicifuga dahurica extracts on melanogenesis accroding to the various extraction methods
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Lee Yun-Jung
Song Hyun-Woo
Lee Bo-Ri
Na Hye-Rim
Song Bong-Joon
Lee Young-Mi
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Abstract
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Objectives: Excessive melanin production leads to skin pigmentation, which causes various cosmetic and health problems. Citrus unshiu Markovich peel (CS) and Cimicifuga dahurica (CD) have long been widely used as a oriental medicinal plant because of their pharmacological properties including anti-ulcer, anti-oxidant, and anti-inflammatory properties.
Methods: In this study, we investigated the inhibitory effects of CS, CD extracts or CS:CD=1:2 mixture on melanogenesis according to the various extraction methods. CS and CD extracted were prepared by ethanol extraction (EE), ultrasonification extraction (USE), Supercritical extraction (SCE), reflux extraction (RE), respectively.
Results: DPPH radical scavenging and tyrosinase inhibitory activity of CD extracts or CS:CD=1:2 mixture were increased in dose-dependent manners. In addition, we evaluated the effect of CS, CD extracts or CS:CD=1:2 mixture on tyrosinase activity and melanogenesis in α-melanocyte stimulating hormone-induced B16-F10 melanoma cells. CS, CD extracts or CS:CD=1:2 mixture significantly inhibited tyrosinase activity and melanogenesis at 10-200 μg/mL.
Conclusions: Therefore, our study suggests that CS and CD extracts have potential as a safe treatment for excessive pigmentation or as a natural ingredient in cosmetics.
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KEYWORD
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Citrus sunki, Cimicifuga dahurica, skin?whitening, antioxidant, melanogenesis
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